Uploaded image for project: 'The Virtual Brain'
  1. The Virtual Brain
  2. TVB-2460

Project planning and discussions VBC

    XMLWordPrintable

    Details

    • Type: Task
    • Status: Resolved
    • Priority: Major
    • Resolution: Fixed
    • Affects Version/s: None
    • Fix Version/s: None
    • Component/s: None
    • Labels:
      None
    • Epic Link:
    • Sprint:
      TVB release 2.0
    • TVB-C Task:
      6.5 TVB-C Architecture

      Description

      Task 5.5 Information fusion and model integration in a 3D scaffold that can be parameterized for personalized simulation
      (M25-M48)

      To enable clinical scientists and biologists to use our system of information fusion and integrative models, we will work
      on an enhancement of the above-mentioned interface to enable it to use personalized data and link that personalized
      data to knowledge-based models. The resulting 3D scaffold will support personalized simulation by allowing non-IT
      researchers to use the individual 3D organization of the personal human brain for information fusion with “personalized”
      graph model of mechanisms. As a consequence, the 3D scaffold embedded in the multi-viewer developed in Task 3.1
      will enable the parametrization of personalized simulations of individual brain physiology. Methods: Enable the 3D
      viewer to load individual geometries and coordinates of personalized brains. Parameterize simulation models using these
      individual geometries and coordinates and “inject information” from graph-based mechanism models that may even
      contain individual SNP patterns. Develop the algorithmic approach that estimates the impact size of effects at pathway
      level on brain network models. Make assumptions on the effects that the perturbation of pathways and mechanisms have
      on the individual brain (given individual genetics, individual dysregulation of pathway, individual BNM graph model)
      and simulate the personalized outcome using the STEP approach in TVB.

      LEAD: Codemart
      Partners involved: CHARITE, Fraunhofer, AMU, CODEBOX

       

      Task 6.3 Information fusion and model integration in a 3D scaffold that can be parameterized for personalized simulation
      (M24-M46)
      One of the key objectives of this project is the integration of molecular level mechanism information with the
      personalized brain physiology simulation capacity of TVB. This task will be addressed in WP8. To enable clinicians,
      students and scientists to use our system for information fusion and integrative modelling, we will work on an
      enhancement of the above-mentioned interface to enable it to use personalized data and link it to personalized data
      to knowledge-based models. The resulting 3D scaffold will support personalized simulation by allowing non-IT
      researchers to use the individual 3D organization of the personal human brain for information fusion with “personalized”
      graph model of mechanisms. As a consequence, the 3D scaffold embedded in the multi-viewer developed in Task
      6.1 will enable the parametrization of personalized simulations of individual brain physiology. Enable the 3D viewer
      to load individual geometries and coordinates of personalized brains. Parameterize simulation models using these
      individual geometries and coordinates and “inject information” from graph-based mechanism models that may even
      contain individual SNP patterns. Develop the algorithmic approach that estimates the impact size of effects at pathway
      level on brain network models. Make assumptions on the effects that the perturbation of pathways and mechanisms have
      on the individual brain (given individual genetics, individual dysregulation of pathway, individual BNM graph model)
      and simulate the personalized outcome using the STEP approach in TVB.
      LEAD: Codemart
      Partners involved: CODEBOX, IBEC, Fraunhofer, AMU, Eodyne

        Gliffy Diagrams

          Attachments

            Issue Links

              Activity

                People

                Assignee:
                Unassigned Unassigned
                Reporter:
                lia.domide Lia Domide
                Votes:
                0 Vote for this issue
                Watchers:
                1 Start watching this issue

                  Dates

                  Created:
                  Updated:
                  Resolved:

                    Time Tracking

                    Estimated:
                    Original Estimate - 13 weeks, 3 days
                    13w 3d
                    Remaining:
                    Remaining Estimate - 0 minutes
                    0m
                    Logged:
                    Time Spent - 11 weeks, 7 hours Time Not Required
                    11w 7h